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Research, Practice, and Policy Implications of Adverse Childhood Experiences [jamanetwork.com]

 

By Edward L. Machtinger, Alicia Lieberman, and Marguerita Lightfoot, JAMA Pediatrics, May 10, 2021

To the Editor We read with great interest the article by Baldwin et al, which contributes to a substantial body of research describing the staggering population-level effects of adverse childhood experiences (ACEs) on many of the most common
causes of adult illness, death, and health disparities.

The principal conclusion the authors derive from their elegantly designed study is that a deterministic use of ACEs scores should not be used to guide individual-level clinical de cision-making. While this recommendation is important for those unfamiliar with ACEs screening, it obscures more important and actionable aspects of their findings.

Adverse childhood experiences are traumatic experiences. It is well known that trauma exposure alone does not predict how an individual will respond. Health sequelae from
trauma exposure develop in the context of one’s ecosystem, including protective and risk factors (eg, the presence or absence of supportive individuals), material resources, and individual strengths and vulnerabilities. To adequately address trauma, individual-level patient assessment requires an understanding of the triad of adversity (ACEs and other traumatic events), protective factors (resources and strengths), and distress (both physical and emotional). This triadic method of trauma inquiry is the framework we are developing in the California ACEs Learning and Quality Improvement Collaborative (CALQIC), a 53-clinic statewide learning collaborative that is a pillar of California’s ACEs Aware initiative. This framework, Trauma Inquiry for Adversity Distress and Strengths (TRIADS), as with most clinical tools in the emerging fields of ACEs and trauma-informed health care, is still formative and undergoing evaluation. But this comprehensive approach is more representative of how ACEs screening is being introduced into clinical settings than the stand-alone method that the authors describe.

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I believe the publication of Baldwin's article and similar articles by JAMAPEDS, and other professional journals, is part of a subtle and not so hidden attempt to attack medical and therapeutic intervention in our culture's pervasive epidemic of child maltreatment trauma and the harm it causes. This is a great study but its flavor is to criticize case finding instead of encouraging it. Below you will find the essence of a letter I sent to JAMAPEDS  about Baldwin's distorting  and discouraging conclusions - which they rejected. Machtinger et al are right but not forceful enough in their response.

Baldwin et al’s  prospective study in JAMA of the incidence of adverse childhood experiences (ACEs) and subsequent occurrence of physical and mental disease after 18 and 45 years does provide a valuable addition of the longitudinal validation of ACEs' studies. It's main focus though is harmful: that population studies cannot predict disease in individuals. This is not new and, in fact, is valid throughout clinical medicine. This detracts from the significance and generally overlooked pathophysiologic impact of child abuse and neglect (CAN) trauma which Baldwin’s study does confirm. Merrick et al from the CDC document the morbidities epidemiologically associated with CAN and use the "population attributable fraction (PAF)"or risk  of CAN being associated with specific diseases, to demonstrate that the PAF of CAN for coronary heart disease (which has been under appreciated) is 12.6%. While PAF is an epidemiologic abstraction and does not aid in diagnosis or treatment, its significance is dramatically highlighted by looking at the published PAFs for coronary artery disease from several common conditions - which are the basis of many standard preventive interventions: for treatment adjusted blood pressure equal or greater than 130 mmHg, 28%, for treatment adjusted non-HDL cholesterol equal or greater than 130 mg/dl, 17%, for smoking, 9.8%, and for diabetes 9.6%. Attention to history of CAN trauma in adults does increase the effectiveness of preventive interventions.

Looking at the relation between epidemiology and individual prevention and treatment throughout medicine from another perspective: we choose to treat asymptomatic people with high cholesterol with statins to prevent coronary heart disease. In fact, because of the pervasive truth that Baldwin emphasizes a doctor needs to treat 60 people for 5 years to avoid one myocardial infarction. Nonetheless this is the standard of care and on a macro scale has been effective. On the other hand, attention to the long term morbidities associated with a history of CAN trauma in adults has been overlooked, even ignored. Thus the development of evidence based treatments has been delayed. The epidemic of child abuse and neglect and its consequent morbid effects demands increased attention, not criticism like Baldwin's.

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