ACEs Research Corner — August 2019


[Editor's note: Dr. Harise Stein at Stanford University edits a web site -- -- that focuses on the health effects of abuse, and includes research articles on ACEs. Every month, she's posting  the summaries of the abstracts and links to research articles that address only ACEs. Thank you, Harise!! — Jane Stevens]

Clemens V, Berthold O, Witt A, et. al.
Child maltreatment is mediating long-term consequences of household dysfunction. Eur Psychiatry. 2019 May;58:10-18. PMID: 30743239
From a national German survey, ACEs linked to household dysfunction were associated with increased risk for all subtypes of child maltreatment: household member mental illness (Odds Ratio for child maltreatment 4.95-5.55), substance misuse (OR 5.32-6.98), violence against the mother (OR 4.43-10.26), incarceration (OR 6.11 – 14.93), and parental separation (OR 3.37-4.87).

Ports KA, Holman DM, Guinn AS, et. al.
Adverse Childhood Experiences and the Presence of Cancer Risk Factors in Adulthood: A Scoping Review of the Literature From 2005 to 2015. J Pediatr Nurs. 2019 Jan - Feb;44:81-96. PMID: 30683285
This review highlights the growing body of research connecting ACEs to cancer risk factors, particularly alcohol, obesity, and tobacco, with fewer studies investigated the links between ACEs and chronic inflammation or infectious agents. Not included are publications investigating associations between ACEs and environmental carcinogens, hormones, immunosuppression, radiation, or ultraviolet radiation. “Mitigating the impact of ACEs may provide innovative ways to effect comprehensive, upstream cancer prevention.” 

Bürgin D, O'Donovan A, d'Huart D, et. al.
Adverse Childhood Experiences and Telomere Length a Look Into the Heterogeneity of Findings-A Narrative Review. Front Neurosci. 2019 May 22;13:490. PMID: 31191214
Analysis of the sometimes conflicting findings in research relating ACEs and telomere length (TL) — a measure of cellular aging.  “Overall, the studies indicated a negative association between ACEs and TL, although many papers presented mixed findings and about a quarter of eligible studies found no association.” 

Campbell JA, Farmer GC, Nguyen-Rodriguez S, et. al.
Relationship between individual categories of adverse childhood experience and diabetes in adulthood in a sample of US adults: Does it differ by gender? J Diabetes Complications. 2018 Feb;32(2):139-143. PMID: 29217352
Of 48,526 adults across 5 states, four categories of ACEs were associated with increased risk of adult diabetes, with no difference in gender — sexual abuse, verbal abuse, physical abuse, and having a parent with mental illness.

Vaughn MG, Salas-Wright CP, Huang J, et. al.
Adverse Childhood Experiences Among Immigrants to the United States. J Interpers Violence. 2017 May;32(10):1543-1564. PMID: 26112971
From a national survey, “With the exception of neglect, the prevalence of ACEs were markedly higher among native-born Americans and second-generation immigrants compared with first-generation immigrants.”

Anthony RE, Paine AL, Shelton KH.
Adverse Childhood Experiences of Children Adopted from Care: The Importance of Adoptive Parental Warmth for Future Child Adjustment. Int J Environ Res Public Health. 2019 Jun 22;16(12). pii: E2212. PMID: 31234480
For 374 British children adopted from care, 42% of the children had experienced 4+ ACEs. Mood and behavioral problems were significantly higher than the UK general population, but these outcomes were lessened by adoptive parental warmth.

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