Safeguards for Youth is a compilation of the latest data on promoting California children’s health and well-being. The data describe protective factors and supportive services, both of which are critical to building a solid foundation for life and addressing the effects of childhood adversity. Protective factors highlight the importance of preventive health care, a strong start in education, and a nurturing school community. Supportive services address adverse experiences such as health challenges, abuse, and family poverty. These data stress the urgency for advocacy and policy change to safeguard California’s future generations.