Skip to main content

Anyone ever see anything published to connect ACE's with CTE or Tau protein pathologies?

Does anyone know of any (additional) published or other materials (see below) that address possible connections between persons having a high ACE's (adverse childhood experiences) score or lifetime chronic (toxic, allostatic-load) stress with persons having chronic traumatic encephalopathy, CTE and/or abnormal tau protein pathologies?
Given that the mind, consciousness, and mentality are biological, so too, necessarily, is culture; Culture is biology.
A correlation between ACE's and either CTE or tau pathologies would be the equivalent of "behaviorally transmitted neurodegeneration" - a staggering concept - and if true, one that hints at a larger-picture socio-cultural evolutionary homeostasis between competitive-scarcity-fear-based and cooperative-abundance-based mindsets writ-large. A connection that would perhaps be visible both economically and politically at the largest scales - and that may be playing out in the present day, some would surely argue. 
Much to think on, yes?
To reiterate; Has anyone ever see anything published to connect ACE's with CTE or Tau protein pathologies?
ACE has been associated with high CRP, c-reactive protein markers.
High CRP has been associated with high tau-protein markers.
Following a transitive logic, one may thus reasonably hypothesize an association between high ACE and high tau-protein measures.
BiPolar & Borderline D-O-E-S result in ATYPICAL NEURODEGENERATION that is focused on the LEFT HIPPOCAMPI and Frontal Neurocortex -  ATYPICAL because it is not GLIAL NEUROTOXICITY but FAMILIAL PERSONALITY DISORDER related  - Which corroborates this early writing by myself, found if you Google "BEHAVIORAL TRANSMISSION OF NEURODEGENERATION" in brackets...

cis pT231-Tau Drives Neurodegeneration in Bipolar Disorder.

Naserkhaki R, et al. ACS Chem Neurosci. 2019.


Bipolar disorder is a complex neuropsychiatric disorder, characterized by intermittent episodes of mania and depression. Recent studies have indicated argyrophilic grains, composed of hyperphosphorylated tau, are observable in postmortem brains of bipolar patients. It remains uncertain how tau hyperphosphorylation results in neurodegeneration upon the disease. Recent studies have demonstrated that phosphorylated tau at Thr231 exists in two distinct cis and trans conformations, in which cis pT231-tau is highly neurotoxic and acts as an early driver of tauopathy in several neurodegenerative diseases. We herein employed an in vitro model, which resembles some aspects of bipolar disorder, to study the cis p-tau mediatory role. We established GSK3β overexpressing SH-SY5Y cells and examined cell viability, cis p-tau formation, and lithium effects by immunofluorescence and flow cytometry. We found an increase in cis p-tau levels as well as viability decrease in the cell model. Furthermore, we discovered that lithium treatment inhibits cis p-tau formation, resulting in diminished cell death. We also examined BD and healthy human brain samples and detected cis p-tau in the patients' brains. Our results show that tauopathy, observed in bipolar disorder, is being mediated through cis p-tau and that a conformer could be the cause of neurodegeneration upon the disease. Our findings would suggest a novel therapeutic target to fight the devastating disorder.

Brain Behav Immun. 2018 Mar;69:582-590. doi: 10.1016/j.bbi.2018.02.007. Epub 2018 Feb 16.

Adverse childhood experiences and adult inflammation: Findings from the 1958 British birth cohort.

Psychosom Med. Author manuscript; available in PMC 2017 Oct 29.
Published in final edited form as:
PMCID: PMC5660872
PMID: 24933013

From Childhood Trauma to Elevated C-Reactive Protein in Adulthood: The Role of Anxiety and Emotional Eating


The Relationship between Tau Protein and C-Reactive Protein during Ischemic Stroke (P01.218)

Joanna BielewiczJacek KurzepaUrszula ChyrchelBeata DanilukHalina Bartosik-PsujekZbigniew Stelmasiak


Images (1)
  • a FB heart pic with infant feet
Last edited by Michael a Sirbola
Original Post
© 2020 All rights reserved.