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Reply to "Epigenetics & intergenerational trauma"

The early intergenerational family therapists (Bowen with anxiety, Normal Paul with grief, Framo with object relations and Ivan Boszormenyi-Nagy with reciprocity and loyalties) focused on psychosocial adaptations, not altered genetics, to explain transgenerational transmission of symptoms.  They would have been laughed at if they did- the scientific inquiry was not there. We know know that stress and trauma affect the substance of life- DNA. Exposure can damage telomeres, the end caps of the DNA strands (chromosomes) where genes are located.

How chronic stress is harming our DNA

https://www.apa.org/monitor/2014/10/chronic-stress

Stress, Aging, and Telomeres

https://www.stress.org/stress-aging-and-telomeres

Telomere Shortening and Stress

https://www.azolifesciences.co...ning-and-Stress.aspx

Early-Life Stress Affects Telomeres Later

https://www.the-scientist.com/...elomeres-later-32742

There is increasing evidence that subsequent generations are affected.


Can Childhood Adversity Affect Telomeres of the Next ...

ajp.psychiatryonline.org › doi › appi.ajp.2019.19111161
 
Jan 1, 2020 - We already know that this direct transmission of telomere length can occur with very short telomeres (10) and with long telomeres (affecting both first and second generations) (16). Thus, it is feasible that stress-related moderately shorter gamete telomeres are directly transmitted to future generations of offspring.

Intergenerational Transmission of Depression: Telomeres

womensmentalhealth.org › posts › intergenerational-tra...
 
Apr 30, 2015 - Intergenerational Transmission of Depression: Telomere Shortening and Cortisol Reactivity in Girls at High Risk for Depression. By MGH ...

Intergenerational Transmission of Paternal ... - Nature

www.nature.com › scientific reports › articles
 
Aug 2, 2017 - The second purpose of this study was to examine the paternal transmission of telomere length (TL) by investigating its epigenetic regulation.
by H Hehar - ‎2017 - ‎Cited by 5 - ‎Related articles

Intergenerational Transmission of Childhood Trauma? Testing ...

www.sciencedirect.com › science › article › pii
 
2 days ago - Substantiated child sexual abuse exposure was not associated with shorter telomeres in adulthood. •. Longer maternal telomere length and ...

Childhood adversity, social support, and telomere ... - NCBI

www.ncbi.nlm.nih.gov › pmc › articles › PMC5705286
 
Oct 5, 2017 - In turn, this has potential significance for intergenerational transmission of telomere length. The predictive value of markers of biological versus ...
by AM Mitchell - ‎2018 - ‎Cited by 26 - ‎Related articles

Childhood adversity, social support, and telomere length ...

 
Oct 5, 2017 - Childhood adversity, social support, and telomere length among perinatal ... significance for intergenerational transmission of telomere length.
by AM Mitchell - ‎2018 - ‎Cited by 25 - ‎Related articles

The contribution of parent-to-offspring transmission of ...

www.biorxiv.org › content
 
Mar 5, 2018 - The contribution of parent-to-offspring transmission of telomeres to the ... of trans-generational (i.e., “direct”) inheritance of telomere length.
by DA Delgado - ‎2018 - ‎Cited by 8 - ‎Related articles

Stress, Telomeres, and Psychopathology: Toward a Deeper ...

www.annualreviews.org › annurev-clinpsy-032816-045054
 
Jump to INTERGENERATIONAL TRANSMISSION OF TELOMERE ... - INTERGENERATIONAL TRANSMISSION OF TELOMERE LENGTH. TL has high genetic heritability of approximately 50% (Broer et al. 2013), but new research suggests that it is also directly transmitted from germ line telomeres (i.e., sperm and eggs).
by ES Epel - ‎2018 - ‎Cited by 37 - ‎Related articles

Paternal age at conception effects on offspring telomere ...

journals.plos.org › plosgenetics › article › journal.pgen....
 
Feb 14, 2019 - Adaptive intergenerational effects are more likely to emerge when ... The contribution of parent-to-offspring transmission of telomeres to the ...
by DTA Eisenberg - ‎2019 - ‎Cited by 3 - ‎Related articles
 
There is also evidence that this process can be addressed as and changed as Jane has suggested:
 

Can meditation slow rate of cellular aging? Cognitive stress ...

www.ncbi.nlm.nih.gov › pmc › articles › PMC3057175
 
Across controlled studies, mindfulness meditation appears to improve physical health symptoms and functioning across a variety of disorders, and increases measures of mental health, including reduced negative affect and increased quality of life. ... It is linked to cardiovascular disease, as well as telomere shortening.
by E Epel - ‎2009 - ‎Cited by 386 - ‎Related articles
 
 

Zen meditation, Length of Telomeres, and the Role of ... - NCBI

www.ncbi.nlm.nih.gov › pmc › articles › PMC4859856
 
Feb 22, 2016 - The possible pathway between meditation and telomere length seems to be that (Schutte and Malouff 2014) mindfulness leads to individuals experiencing less stress, anxiety, and depression, which are all thought to be associated with cortisol level, and this association seems to be associated with telomerase activity.
by M Alda - ‎2016 - ‎Cited by 44 - ‎Related articles
Abstract · ‎Method · ‎Results · ‎Discussion

Telomere length correlates with subtelomeric DNA ... - Nature

www.nature.com › scientific reports › articles
 
Mar 12, 2020 - Mindfulness and meditation techniques have proven successful for the reduction of stress and improvement in general health. In addition ...
by M Mendioroz - ‎2020 - ‎Related articles

Insight meditation and telomere biology: The effects of ...

www.sciencedirect.com › science › article › pii
 
Telomeres and the enzyme telomerase interact with a variety of molecular ... Mindfulness Based Stress Reduction (MBSR) programs (Carlson et al., 2015, ...
by QA Conklin - ‎2018 - ‎Cited by 29 - ‎Related articles
 

The Science of Meditation's Effects on Aging | HuffPost Life

www.huffpost.com › entry › the-science-of-meditations...
 
Dec 8, 2015 - Given that mindfulness practice has been historically connected to reduced ruminative thinking and stress, Epel's research team suggested in a 2009 follow-up paper that mindfulness meditation may also have potential positive effects on preservation of telomere length and telomerase activity.
 

Association among dispositional mindfulness, self ...

bmcpsychology.biomedcentral.com › articles
 
Jul 22, 2019 - A key biological marker associated with aging at the cellular level is leukocyte telomere length (LTL) [1]. Telomeres cap the ends of chromosomes ...
by SL Keng - ‎2019 - ‎

 


Physical Activity and Nutrition: Two Promising Strategies for ...

www.ncbi.nlm.nih.gov › pmc › articles › PMC6316700
 
Jump to Telomere Regulation by Physical Activity - ... exercise are sufficient to protect telomere health, while ... Finally, leukocyte telomere length was 11% ...

 

 

Five Foods That Protect Your Telomeres and Extend Your Life ...

www.ornish.com › zine › five-foods-that-protect-telom...
 
Research shows that those with higher levels of antioxidants such as Vitamin C, E and selenium tend to have longer telomeres. Fruits and vegetables are the best sources of antioxidants, which is why a plant-based diet is highly recommended.

Exercise, Telomeres, and Cancer: “The Exercise ... - Frontiers

www.frontiersin.org › articles › fphys.2018.01798 › full
 
Dec 18, 2018 - In summary, there is evidence that exercise leads to less telomere ... that included weight loss strategies with exercises and nutrition and 58 to ...

The bacteria in your gut may reveal your true age | Science ...

www.sciencemag.org › news › 2019/01 › bacteria-your...
 
Jan 11, 2019 - Scientists say microbiome is a surprisingly accurate biological clock. ... from your ability to digest food to how your immune system functions. ... use to predict biological age, including the length of telomeres—the tips of ..
Last edited by Michael McCarthy
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